论文部分内容阅读
为对有机磷除草剂胺草灵(Amiprophos)的迟发性神经毒性的机制进行探讨,合成了~(35)S-胺草灵。并用该标记化合物对胺草灵在大白鼠体内的代谢作了初步研究。结果表明大白鼠摄入~(35)S-胺草灵后48小时内能排出占剂量90％左右的放射性硫。此尿中放射性硫中硫酸根量占50％左右;酸性条件下可提取的放射性硫占剂量10％左右。可提取
In order to investigate the mechanism of delayed neurotoxicity of organophosphorous herbicide Amiprophos, ~(35)S-aminocampulin was synthesized. A preliminary study was conducted on the metabolism of aminoxam in rats using the labeled compound. The results showed that the rats were able to discharge about 90% of the dose of radioactive sulphur within 48 hours after the (35)S-aminosulfate was ingested. The amount of sulfuric acid in radioactive sulfur in urine accounts for about 50%, and radioactive sulfur extractable in acidic conditions accounts for about 10% of the dose. Extractable