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目的评价单剂量丙种球蛋白联合白蛋白在治疗新生儿ABO溶血中的疗效。方法将2004年10月至2010年10月在我院住院治疗的81例新生儿ABO溶血患儿分为治疗组和对照组,比较两组间治疗前后的血清总胆红素水平及黄疸消退时间。结果治疗后72h,单剂量丙种球蛋白联合白蛋白治疗组,血清总胆红素为(78.51±16.58)μmol/L、黄疸消退时间(7.6±1.3)d,对照组为(102.64±21.86)μmol/L、(9.4±1.5)d,差异有统计学意义(P<0.05)。结论单剂量丙种球蛋白联合白蛋白可有效阻断ABO溶血过程,迅速降低血清胆红素水平,缩短黄疸消退时间。
Objective To evaluate the efficacy of single-dose gamma globulin combined with albumin in the treatment of neonatal ABO hemolysis. Methods Eighty-one neonates with ABO hemolysis hospitalized in our hospital from October 2004 to October 2010 were divided into treatment group and control group. The levels of serum total bilirubin and jaundice were compared between the two groups before and after treatment . Results At 72h after treatment, the total bilirubin level was (78.51 ± 16.58) μmol / L and the jaundice subsided time was (7.6 ± 1.3) d in the single-dose gamma globulin combined with albumin treatment group and (102.64 ± 21.86) μmol in the control group /L, (9.4 ± 1.5) d, the difference was statistically significant (P <0.05). Conclusion Single dose of gamma globulin combined with albumin can effectively block the hemolytic process of ABO, rapidly reduce the level of serum bilirubin, shorten the jaundice subsided time.