最近有文章指出,抗癌药顺式-二氯二氨铂(DDP)是不稳定的,不应稀释或在含氯化钠量不小于0.9％的静脉注射赋形剂中给药。并且还提到葡萄糖存在使稳定性问题更为严重。经我们研究结果证实,稳定性取决于氯化物的浓度,即使氯化钠的浓度仅0.1％那样低时,DDP的减失相当缓慢。我们用高压液相色谱分析法追踪25℃时完整的DDP在水溶液中的消失。并研究了对DDP减失率的影响因素;(a)DDP的初浓 Recent articles point out that the anticancer drug cis-Dichloroplatinum (DDP) is not stable and should not be diluted or administered in intravenous vehicles containing sodium chloride in an amount of not less than 0.9%. It is also mentioned that the presence of glucose worsens the stability problem. The results of our study confirm that the stability depends on the concentration of chloride, and the loss of DDP is relatively slow even when the sodium chloride concentration is as low as 0.1%. We followed the disappearance of intact DDP in aqueous solution at 25 ° C by high pressure liquid chromatography. And studied the factors affecting the rate of loss of DDP; (a) The initial concentration of DDP