前列腺特异性同源框基因NKX3.1研究进展

来源 :国外医学 | 被引量 : 0次 | 上传用户：xiaokexiaoai1314

【摘要】

：

NKX3.1是新近发现的前列腺特异性和雄激素调节基因,属于同源框基因家族.人类NKX3.1基因位于染色体8p21上,在人前列腺组织高度表达,为前列腺组织特异性,与前列腺组织发生和发

【作者】

：

杨国胜陈昭典

【机构】

：

浙江大学医学院附属第一医院泌尿外科

【出处】

：

国外医学

【发表日期】

：

2004年期

【关键词】

：

同源框基因 NKX3.1 前列腺肿瘤雄激素

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NKX3.1是新近发现的前列腺特异性和雄激素调节基因,属于同源框基因家族.人类NKX3.1基因位于染色体8p21上,在人前列腺组织高度表达,为前列腺组织特异性,与前列腺组织发生和发育有关,是前列腺特异性肿瘤抑制基因.NKX3.1基因在前列腺组织表达状态呈现雄激素时间和浓度依赖性,并与前列腺癌发生发展以及前列腺癌的类型、分期和体积关系密切,有望成为诊断和治疗前列腺癌的有效工具.

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前列腺特异性同源框基因NKX3.1研究进展

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