论文部分内容阅读
局部晚期口腔癌进展迅速,预后差,术后复发率高。该文旨在评估术前诱导化疗联合手术治疗的效果及安全性。临床Ⅲ期前瞻性随机试验,实验组患者接受术前诱导化疗,手术或联合术后放疗(Chemo Group),对照组患者接受手术或联合术后放疗(Control Group)。结果 :451例患者随机分入Chemo Group(n=226)、Control Group(n=225),89.1%的患者为临床Ⅲ/Ⅳ期。在局部复发率、无瘤生存率及总生
Local advanced oral cancer progresses rapidly, with poor prognosis and high postoperative recurrence rate. The purpose of this paper is to evaluate the efficacy and safety of preoperative induction chemotherapy combined with surgical treatment. In the prospective randomized clinical phase III trial, patients in the experimental group received preoperative chemo induction, surgery or combined with postoperative radiotherapy (Chemo Group), and patients in the control group underwent surgery or combined with postoperative radiotherapy (Control Group). RESULTS: 451 patients were randomly assigned to Chemo Group (n = 226) and Control Group (n = 225). 89.1% of patients were in clinical stage III / IV. In the local recurrence rate, tumor-free survival and total health