IQ对黑腹果蝇生殖细胞的遗传毒性

来源 :卫生毒理学杂志 | 被引量 : 0次 | 上传用户:smalldong224
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高温烹调含有蛋白质的食物可以产生某些有遗传损害的物质,用Ames试验业已证明煎烤鱼、肉外皮的硷性提取物能使回变数剧烈增加。从油炸牛肉或沙丁鱼中已提取分离和鉴定出IQ[2-氨基-3-甲基咪唑(4,5f)喹啉]等10余种杂环胺类化合物,其中IQ首先从加热的牛肉提取物中分离,并能人工合成。大小鼠实验证明,长期喂饲含有300ppmIQ饲料可以引起肝细胞癌、肺腺癌和皮 High-temperature cooking of protein-containing foods can produce certain substances with genetic damage, with the Ames test has shown that grilled fish, meat extract alkaline extract can make the return number increased dramatically. More than 10 kinds of heterocyclic amine compounds such as IQ [2-amino-3-methylimidazol (4,5f) quinoline] have been isolated and identified from fried beef or sardines, in which IQ is first extracted from heated beef Material separation, and can be synthesized. Large and small mice experiments show that long-term feeding containing 300ppmIQ feed can cause hepatocellular carcinoma, lung adenocarcinoma and skin
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