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目的分析和研究多发性骨髓瘤(MM)的临床特征。方法对38例MM患者的临床资料进行回顾性分析。结果骨痛与乏力是最常见的首发症状,贫血及消瘦多见,免疫分型以IgA、IgG型最常见,T-VAD及T-MP方案治疗初发患者38例,有效率达76.3%,生存60个月以上5例,最长73个月,目前尚生存,2例复发患者给予硼替佐米-VAD化疗后获得部分缓解,维持时间超过20个月,目前仍在随访观察中。结论 MM起病隐匿,临床表现多样化。沙利度胺联合传统化疗方案取得了较好的疗效,对于复发患者加用硼替佐米的治疗,提高缓解率及生存期。
Objective To analyze and study the clinical features of multiple myeloma (MM). Methods The clinical data of 38 MM patients were retrospectively analyzed. Results Pain and fatigue were the most common initial symptoms. Anemia and emaciation were more common. IgA and IgG were the most common immunophenotypes in 38 patients with initial onset of T-VAD and T-MP, with an effective rate of 76.3% Survival of more than 60 months in 5 cases, up to 73 months, is still alive, 2 patients relapsed patients given bortezomib-VAD chemotherapy was partially relieved, maintenance of more than 20 months, is still under follow-up observation. Conclusion MM occult onset, clinical manifestations of diversification. Thalidomide combined with traditional chemotherapy has achieved good results, for the treatment of relapsed patients with bortezomib, to improve the remission rate and survival.