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目的探讨幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的影响,为临床诊治提供参考依据。方法选取2015年2月-2016年9月医院收治的56例胃溃疡且幽门螺杆菌阳性患者为A组,同期56例胃溃疡且幽门螺杆菌阴性患者为B组,另选同期56名健康者为C组,比较三组胃蛋白酶原及胃肠动力状态相关指标,同时比较A组不同类型幽门螺杆菌感染患者的检测结果。结果 A组的血清胃蛋白酶原相关指标均低于B组及C组,B组则低于C组,A组胃肠动力状态相关指标均差于B组及C组,B组则差于C组,且A组不同类型幽门螺杆菌感染患者的检测结果也存在显著性差异(P均<0.05),检测结果间均有显著性差异。结论幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的不良影响较大,且幽门螺杆菌的类型对其影响也较为明显,因此,应重视对胃溃疡患者进行幽门螺杆菌的监测。
Objective To investigate the effect of Helicobacter pylori infection on pepsinogen and gastrointestinal motility in patients with gastric ulcer and provide a reference for clinical diagnosis and treatment. Methods 56 patients with gastric ulcer and H. pylori-positive patients admitted to our hospital from February 2015 to September 2016 were enrolled as Group A, 56 patients with gastric ulcer and Helicobacter pylori-negative patients as Group B in the same period, 56 healthy persons For the C group, compared the three groups of pepsinogen and gastrointestinal motility related indicators, while A group of different types of Helicobacter pylori infection in patients with the test results. Results Serum pepsinogen related indicators in group A were lower than those in group B and C, while those in group B were lower than those in group C. The relative indexes of gastrointestinal motility in group A were lower than those in group B and C There was also a significant difference in the test results among different types of H. pylori infection in group A (all P <0.05). There was a significant difference between the test results. Conclusions Helicobacter pylori infection has a great effect on pepsinogen and gastrointestinal motility in patients with gastric ulcer, and the type of Helicobacter pylori is more obvious. Therefore, we should pay more attention to the monitoring of Helicobacter pylori in gastric ulcer patients .