论文部分内容阅读
目的观察阿司匹林耐受不良三联征对肺通气功能的改变及哮喘控制情况。方法收集2007年1月至2012年10月住院的阿司匹林三联征患者36例(AIT组),收集合并变应性鼻炎的支气管哮喘患者和一般的支气管哮喘患者各35例(鼻炎合并哮喘组和哮喘组)。比较三组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量的百分比(FEV1%FVC)、呼气峰流速(PEF)、哮喘控制测试(ACT)、哮喘控制问卷(ACQ)。结果 AIT组FVC、FEV1、FEV1%FVC、PEF均低于哮喘组,两组差异有统计学意义(P<0.05)。AIT组与鼻炎合并哮喘组比较,FVC、FEV1、PEF差异无统计学意义,但两组FEV1%FVC差异有统计学意义(P<0.05)。AIT组ACT评分为14.2±4.5,ACQ评分为2.7±1.5,与哮喘组比较差异有统计学意义(P<0.05),与鼻炎合并哮喘组比较差异无统计学意义(P>0.05)。结论 AIT患者有较严重的气道炎症和较高的气道反应性,其肺功能明显下降且对哮喘控制不佳。FEV1%FVC是一个有效、灵敏的观察指标用来检测和评价AIT。
Objective To observe the change of pulmonary ventilation function and asthma control in aspirin-tolerant triad. Methods Thirty-six patients (AIT group) with asymptomatic aspirin admitted from January 2007 to October 2012 were enrolled and 35 patients with bronchial asthma and allergic rhinitis were collected. group). FVC, FEV1, FEV1% FVC, PEF and asthma control test were compared between the three groups (FVC, FEV1, ACT), Asthma Control Questionnaire (ACQ). Results The FVC, FEV1, FEV1% FVC and PEF in AIT group were lower than those in asthma group, the difference was statistically significant (P <0.05). There were no significant differences in FVC, FEV1 and PEF between AIT group and rhinitis group, but there was significant difference between the two groups in FEV1% FVC (P <0.05). The ACT score of AIT group was 14.2 ± 4.5, and the ACQ score was 2.7 ± 1.5, which was significantly different from asthma group (P <0.05). There was no significant difference between AIT group and asthma group (P> 0.05). Conclusions AIT patients have more serious airway inflammation and higher airway reactivity with markedly decreased pulmonary function and poor control of asthma. FEV1% FVC is a valid and sensitive indicator for the detection and evaluation of AIT.