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目的:探讨大脑中动脉深穿支单个腔隙性梗死病灶的临床特点及抗血小板药物疗效。方法:收集2014年1月至2015年10月在北京市海淀医院神经内科住院的72 h以内发生大脑中动脉(middle cerebral artery,MCA)深穿支供血区域单个腔隙性梗死患者60例,将其根据梗死部位及载体动脉是否存在病变分为2组:腔隙性脑梗死伴有MCA病变组和腔隙性脑梗死不伴有MCA病变组,分别对这2组的病人进行脑血管病危险因素(性别、年龄、高血压、血压变异性、糖尿病、冠心病、脑卒中、吸烟)、临床特点(NIHSS评分、白质高信号)及抗血小板药物治疗3月后m RS评分比较。结果:两组在高血压、糖尿病、冠心病、脑卒中、吸烟、血压变异性、NIHSS、白质高信号及抗血小板物治疗3月后m RS方面有统计学差异(P<0.05)。结论:根据梗死部位及MCA病变,提示了MCA深穿支单个腔隙性梗死临床特点、病因及发病机制的多样性。因此需采取不同的治疗措施。
Objective: To investigate the clinical features of single lacunar infarct with deep penetrating branch of middle cerebral artery and its antiplatelet effect. Methods: From January 2014 to October 2015, 60 patients with single lacunar infarction in the area of deep perforating branches of the middle cerebral artery (MCA) within 72 hours in the hospital of neurology of Beijing Haidian Hospital were enrolled. Sixty According to the infarction site and the existence of carrier artery lesions are divided into two groups: lacunar infarction with MCA lesions and lacunar infarction is not associated with MCA lesions group, respectively, these two groups of patients with cerebrovascular disease risk Factors such as gender, age, hypertension, variability of blood pressure, diabetes, coronary heart disease, stroke, smoking, clinical features (NIHSS score, white matter hyperintensities) and anti-platelet therapy mRS score after 3 months were compared. Results: There were significant differences in m RS between the two groups in hypertension, diabetes mellitus, coronary heart disease, stroke, smoking, variability of blood pressure, NIHSS, white matter hyperintensities and antiplatelet 3 months after treatment (P <0.05). Conclusion: According to the infarction location and MCA lesions, the clinical features, etiology and pathogenesis of single lacunar infarction with deep penetrating MCA are suggested. Therefore need to take different treatment measures.