用大黄造成实验性脾虚模型,并引起小鼠肠道内菌群紊乱,其中的双歧杆菌、乳杆菌及拟杆菌菌量均下降,当服用褐多孔菌水煎剂后,这些菌量均上升为正常水平。本研究表明,褐多孔菌不仅对免疫功能具有调节作用,而且对小鼠肠道菌群失调也具有调节功能,并对脾虚的康复具有促进作用。 The model of experimental spleen deficiency caused by rhubarb caused disorder in the intestinal flora of the mice. The amounts of Bifidobacterium, Lactobacillus and Bacteroidetes were all decreased. When the brown bacterium was used as a decoction, the amount of these bacteria increased to normal level. This study shows that Pleurotus ostreatus not only regulates the immune function, but also regulates the disorder of the intestinal flora in mice, and has a promoting effect on the recovery of spleen deficiency.