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目的探讨IL-10以及TGF-β1在妊娠期免疫性血小板减少性紫癜(ITP)及妊娠期血小板减少症(GT)发病中的作用。方法研究组选取2011年7月至2012年3月于北京大学人民医院产科住院择期剖宫产分娩的妊娠期免疫性血小板减少性紫癜(ITP)患者9例以及妊娠期血小板减少症(GT)患者11例,对照组取同期在北京大学人民医院择期剖宫产分娩的健康孕妇16例。采用ELISA方法分别检测三组母血、脐血中IL-10、TGF-β1的浓度,对比妊娠期ITP组、GT组母血及脐血中IL-10、TGF-β1的浓度,并对母血、脐血中IL-10、TGF-β1的浓度与母血血小板、新生儿血小板计数进行相关性分析。结果妊娠期ITP组、GT组母血中IL-10、TGF-β1浓度与对照组母血对比差异无统计学意义(P>0.05),三组脐血中IL-10浓度差异无统计学意义(P>0.05),妊娠期ITP组脐血中TGF-β1浓度与GT组及对照组脐血对比差异无统计学意义(P>0.05),GT组脐血TGF-β1浓度较对照组升高。在妊娠期ITP组及GT组中,母血、脐血中IL-10、TGF-β1浓度与母体及新生儿血小板水平无明显相关性。结论 IL-10、TGF-β1在妊娠期ITP及GT发病中的作用可能与非妊娠期ITP不同,IL-10、TGF-β1在母血及脐血中的浓度与血小板水平无相关性。
Objective To investigate the role of IL-10 and TGF-β1 in the pathogenesis of gestational immune thrombocytopenic purpura (ITP) and gestation thrombocytopenia (GT). Methods The research group selected 9 patients with gestational immune thrombocytopenic purpura (ITP) who had elective cesarean delivery in the obstetrics department of Peking University People’s Hospital from July 2011 to March 2012 and 9 patients with gestational thrombocytopenia (GT) Eleven patients in the control group took the same period in Peking University People’s Hospital elective cesarean delivery of healthy pregnant women in 16 cases. The concentrations of IL-10 and TGF-β1 in maternal blood and umbilical cord blood were detected by ELISA. The concentrations of IL-10 and TGF-β1 in maternal serum and cord blood of gestational ITP group, GT group and GT group were compared. Blood, cord blood IL-10, TGF-β1 concentration and maternal platelet, neonatal platelet count were analyzed. Results There was no significant difference in the concentrations of IL-10 and TGF-β1 in the maternal serum between the pregnant ITP group and the GT group and the control group (P> 0.05). There was no significant difference in the concentrations of IL-10 between the three groups (P> 0.05). The levels of TGF-β1 in umbilical cord blood in gestational ITP group were not significantly different from those in GT group and control group (P> 0.05). The concentration of TGF-β1 in umbilical cord blood of GT group was higher than that of control group . IL-10 and TGF-β1 levels in maternal blood and cord blood were not significantly correlated with maternal and neonatal platelet levels in ITP group and GT group during pregnancy. CONCLUSION: IL-10 and TGF-β1 may play different roles in the pathogenesis of ITP and GT during pregnancy than non-pregnant ITP. The concentrations of IL-10 and TGF-β1 in maternal blood and umbilical cord blood are not correlated with platelet levels.