【摘 要】
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B cell-mediated humoral immunity plays a vital role in viral infections, including chronic hepatitis B virus (HBV) infection, which remains a critical global pu
【机 构】
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School of Environmental and Biological Engineering, Nanjing University of Science & Technology, Nanj
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B cell-mediated humoral immunity plays a vital role in viral infections, including chronic hepatitis B virus (HBV) infection, which remains a critical global public health issue. Despite hepatitis B surface antigen-specific antibodies are essential to eliminate viral infections, the reduced immune functional ca-pacity of B cells was identified, which was also correlated with chronic hepatitis B (CHB) progression. In addition to B cells, T follicular helper (Tfh) cells, which assist B cells to produce antibodies, might also be involved in the process of anti-HBV-specific antibody production. Here, we provide a comprehen-sive review of the role of various subsets of B cells and Tfh cells during CHB progression and discuss current novel treat-ment strategies aimed at restoring humoral immunity. Under-standing the mechanism of dysregulated B cells and Tfh cells will facilitate the ultimate functional cure of CHB patients.
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