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目的探讨P53的表达在不同类型胸腺瘤中的意义。方法选取我科2000年5月至2005年12月29例经病理证实的胸腺瘤手术切除标本,采用SP免疫组化方法检测P53蛋白在胸腺瘤中的表达情况。结果P53阳性表达率分别为:良性胸腺瘤7.70%,恶性胸腺瘤I型50.00%,胸腺癌100%。P53的表达随着肿瘤恶性程度的增高而增加(P<0.05)。P53蛋白表达的阳性率与胸腺组织学类型及是否伴有重症肌无力(MG)无关(P>0.05)。结论P53的表达在不同类型胸腺瘤中差异显著,对于判断胸腺瘤良恶性有重要参考价值。
Objective To investigate the significance of P53 expression in different types of thymomas. Methods Twenty-nine cases of pathologically confirmed thymoma surgical resection specimens from May 2000 to December 2005 were selected. SP immunohistochemistry was used to detect the expression of P53 protein in thymoma. Results The positive rate of P53 expression was as follows: benign thymoma 7.70%, malignant thymoma I type 50.00%, and thymic carcinoma 100%. The expression of P53 increased with the increase of tumor malignancy (P<0.05). The positive rate of P53 protein expression was not related to the histological type of thymus and whether it was associated with myasthenia gravis (MG) (P>0.05). Conclusion The expression of P53 is significantly different in different types of thymoma, and it has important reference value for judging benign and malignant thymoma.