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一、链霉素的副作用链霉素是常用抗结核剂中副作用最多的药剂。在链霉素制剂中有链霉素和双氢基链霉素两种,前者容易引起前庭障碍,后者容易引起听觉障碍。为防止这些副作用,将两者等分混合后,又制成了复合链霉素制剂(在美国叫做Streptoduocin)。从投药方法看,每周两日的方法较每日投与的方法所引起的副作用少,而投药期间越长,则副作用当然也越多。夏合链霉素制剂引起听觉障碍及前庭障碍的确实比较少,但在连续使用八个月以上时,也不见得不能引起这些副作用。使双氢基链霉素再结晶,予以精制,作成了纯粹的及氢链霉素,但Mahady等氏认为对副作用方面并不特别优越。
First, the side effects of streptomycin Streptomycin is the most commonly used antituberculosis agents side effects. Streptomycin in streptomycin and streptomycin two, the former easily lead to vestibular disorders, the latter easily lead to hearing problems. To prevent these side effects, a mixture of streptomycin (called Streptoduocin in the United States) was made after aliquoting the two. From the method of administration, two days a week than the method of daily administration of side effects caused by less, and the longer the administration period, the more the side effects of course. It is true that streptomycin formulations cause less hearing loss and vestibular disorders, but these adverse effects do not necessarily occur when used continuously for more than eight months. The dihydrostreptomycin was recrystallized and refined to make pure and streptomycin, but Mahady et al. Did not find the side effects particularly superior.