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目的应用混合线性模型,分析婴幼儿生长发育轨迹的影响因素,建立生长发育轨迹的预测模型。方法采用SAS软件MIXED过程分析456例足月健康新生儿的生长发育资料,建立基于混合线性模型的0~12月龄婴儿体重生长轨迹预测模型。结果 0~12月龄婴儿体重发育轨迹主要受出生体重、性别、喂养方式、母亲文化程度、家庭经济状况的影响。拟合的混合线性模型不仅考虑了个体内和个体间变异,还可方便地加入个体效应与其他因素的交互项,更客观地解释各因素对婴儿生长发育的影响。结论混合线性模型是研究婴幼儿生长发育规律的一种有效、实用的方法。
Objective To analyze the influential factors of growth and development path of infants and young children by using mixed linear model and establish the prediction model of growth and development trajectory. Methods SAS software MIXED process was used to analyze the growth and development data of 456 full-term healthy newborn infants and establish a prediction model of weight growth trajectories of 0 to 12-month-old infants based on the mixed linear model. Results The body weight of 0 to 12 month-old infants was mainly affected by birth weight, sex, feeding style, mother’s education and family economic status. The fitted mixed linear model not only considers intra-individual and inter-individual variation, but also can easily add interactions between individual effects and other factors to more objectively explain the impact of various factors on infant growth and development. Conclusion Mixed linear model is an effective and practical method to study the growth and development of infants.