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目的探讨扶正减毒颗粒治疗放射性肺损伤的作用机理。方法采用单次大剂量胸部照射制成放射性肺损伤小鼠模型,并与空白组比较,观察扶正减毒颗粒对放射性肺损伤小鼠模型肺组织病理学及MMP-2、MMP-9的干预。结果扶正减毒颗粒能降低模型小鼠肺组织MMP-2、MMP-9的表达、明显减轻放射性肺损伤小鼠肺组织病理学改变(P<0.05,P<0.01)。结论扶正减毒颗粒可减轻急性肺损伤的程度,有效阻止或延缓肺纤维化的形成。
Objective To investigate the mechanism of Fuzheng Yutu Granule in treating radiation-induced lung injury. Methods A rat model of radiation-induced lung injury was established by a single bolus injection of high dose radiation. Compared with the blank control group, we observed the effects of Fuzheng-Jinsuo Granule on lung histopathology and MMP-2 and MMP-9 in mice with radiation-induced lung injury. Results Fuzheng Jusuo Granule can reduce the expression of MMP-2 and MMP-9 in the lungs of mice and significantly reduce the pathological changes of lung tissue (P <0.05, P <0.01). Conclusion Fuzheng attenuated particles can reduce the degree of acute lung injury, effectively prevent or delay the formation of pulmonary fibrosis.