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目的 了解重组干扰素ａ１ｂ的抗病毒活性及其临床效果。方法应用小牛肾传代细胞（ＭＤＢＫ）与 人羊膜传代细胞（ＷＩＳＨ）测定重组干扰素ａ１ｂ的抗病毒活性；应用４０ｕｇ的剂量连续注射３个月观察治疗乙型肝炎的 临床效果。结果在ＭＤＢＫ细胞中测定的活性比在ＷＩＳＨ细胞中高１１．３倍；４０ｕｇ／ｄ重组干扰ａ１ｂ。治疗乙型肝炎有 效，不良反应轻微。结论 建议以重量（ｕｇ）表示重组干扰素的剂量。
Objective To understand the antiviral activity of recombinant interferon alb and its clinical effect. Methods The antiviral activity of recombinant interferon alb was determined by using MDBK and WISH. The clinical effect of hepatitis B was observed by continuous injection of 40ug for 3 months. Results The activity measured in MDBK cells was 11.3 times higher than in WISH cells; 40 ug / d recombination interfered a1b. Hepatitis B treatment effective, minor adverse reactions. Conclusion It is recommended to express the dose of recombinant interferon by weight (ug).