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目的:制备一种治疗软组织损伤的纯中药贴剂—消肿止痛巴布剂。方法:采用正交设计,以消肿止痛巴布剂中延胡索乙素、三七皂苷R1的量为考察指标,测定不同提取工艺样品中延胡索乙素、三七皂苷R1含量,确定最佳提取工艺,然后将药用高分子材料均匀分散在溶剂中待完全溶胀后,与药物浸膏混合均匀后,65℃保温放置一段时间后,涂铺在无纺布上,剪切制成巴布剂并做安全性实验。结果:正交实验结果表明最佳提取方案为A2B3C2,即加4倍量70%乙醇,回流30 min。家兔及豚鼠皮肤安全性实验证明该药无刺激性和过敏性。结论:本贴剂工艺合理,是安全、使用方便的新型外用药物。
Objective: To prepare a pure Chinese medicine patch for the treatment of soft tissue injury - relieving pain and relieving pain cataplasm. Methods: The orthogonal design was used to determine the content of tetrahydropalmatine and notoginsenoside R1 in different extraction process samples, and the best extraction process , And then uniformly dispersed in the solvent of the polymer material to be fully swollen after mixing with the drug extract, 65 ℃ insulation placed for a period of time, spread on non-woven fabric, made of plywood and shear Do safety experiment. Results: The results of orthogonal experiment showed that the optimal extraction scheme was A2B3C2, that is, adding 4 times the amount of 70% ethanol and refluxing for 30 min. Rabbit and guinea pig skin safety tests show that the drug is non-irritating and allergic. Conclusion: The patch process is reasonable, is safe, easy to use new topical drugs.