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目的 :本研究旨在了解基础脉压和随访 4年中脉压水平与脑血管病患者脑卒中再发事件的关系。 方法 :入选 15 2 0例 5年内曾发生过脑卒中 (包括脑出血和梗死 )和一过性脑缺血发作患者。平均年龄 (63 9± 7 6)岁。每半年至少随访 1次 ,随访 4～ 5年。随访中测量血压和收集脑卒中事件证据材料。终点事件评估委员会根据脑卒中证据材料评估脑卒中事件。收缩压 -舒张压 =脉压 ,脉压分 4级 ,即 <45 ,45～ 5 4,5 5～ 64 ,≥ 65mmHg (1mmHg=0 13 3kPa) ,分析不同级别脉压水平与脑卒中再发事件的关系。 结果 :入选患者基础脉压 <45 ,45～ 5 4,5 5～ 64 ,≥ 65mmHg者的脑卒中再发率分别为 9 7% ,12 7% ,16 1%和16 4% ;随访 4年中脉压平均水平 4个级别的脑卒中再发率分别为 8 6% ,14 7% ,17 5 %和 2 7 5 %。 结论 :脑血管病患者基础脉压或随访 4年中平均脉压与脑卒中再发密切相关 ,脉压越大 ,脑卒中再发危险越高。
OBJECTIVE: This study aimed to understand the relationship between basal pulse pressure and recurrent stroke in patients with cerebrovascular disease during 4 years of follow-up. Methods: Fifty-two (60) patients were enrolled in this study who had had a stroke (including intracerebral hemorrhage and infarction) and transient ischemic attack within 5 years. The average age (63 9 ± 7 6) years old. Follow-up at least once every six months, followed up for 4 to 5 years. Blood pressure was measured at follow-up and evidence of stroke events was collected. The Endpoint Assessment Board assesses stroke events based on evidence of stroke. Systolic pressure-diastolic blood pressure = pulse pressure, pulse pressure level 4, that is, <45, 45 ~ 5 4,5 5 ~ 64, ≥ 65mmHg (1mmHg = 0133kPa), analysis of different levels of pulse pressure and stroke recurrence The relationship between the events. Results: The recurrent rates of stroke were 97%, 127%, 161% and 16 4% respectively in patients with underlying pulse pressure <45, 45-5 45-5 64, and ≥ 65 mmHg. After 4 years of follow-up, The recurrent rates of stroke at the four levels of median mean pressure were 86%, 147%, 175% and 275%, respectively. Conclusion: The basic pulse pressure of patients with cerebrovascular disease or mean pulse pressure during follow-up of 4 years is closely related to recurrent stroke. The greater the pulse pressure, the higher the risk of recurrent stroke.