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目的:探讨血浆纤维蛋白原水平与恶性肿瘤的关系,为临床诊断、治疗提供依据。方法:应用SF-8000血凝仪检测健康组、良性肿瘤组、恶性肿瘤未转移组、恶性肿瘤转移组血浆纤维蛋白原含量,并对部分患者进行治疗后跟踪检测,进行血浆纤维蛋白原水平变化与疾病的关系分析。结果:血浆纤维蛋白原水平健康组和良性肿瘤组差异无统计学意义(P>0.05),恶性肿瘤组较前2组明显升高(P<0.01),转移组较未转移组增加明显(P<0.01),治疗缓解患者较治疗前降低(P<0.01),未缓解者治疗前、后血浆纤维蛋白原水平无统计学意义(P>0.05)。结论:血浆纤维蛋白原水平在恶性肿瘤的辅助诊断及疗效判断方面有一定意义。
Objective: To investigate the relationship between plasma fibrinogen level and malignant tumor and provide the basis for clinical diagnosis and treatment. Methods: The plasma fibrinogen levels in healthy group, benign tumor group, non-metastatic group and malignant tumor metastasis group were detected by SF-8000 coagulation analyzer. After treatment, some patients were followed up for detection of plasma fibrinogen level Analysis of the relationship with the disease. Results: The level of plasma fibrinogen was not significantly different between healthy group and benign tumor group (P> 0.05), the malignant tumor group was significantly higher than the former two groups (P <0.01), and the metastasis group was significantly higher than the non-metastatic group (P (P <0.01). The level of plasma fibrinogen was not significantly different between before and after treatment (P> 0.05). Conclusion: The level of plasma fibrinogen has some significance in the diagnosis of malignant tumors and the judgment of curative effect.