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以PCR-SSCP方法，分析30例大肠癌原发灶和15例正常粘膜组织的APC基因MCR区段的突变，发现60％（18／30）的大肠癌原发灶中存在APC基因MCR区段的突变。其突变率与肿瘤发生部位、临床病理分期、组织分化程度及淋巴结转移情况无关。结果表明：APC基因突变是大肠癌发生的早期改变，可见于不典型增生的粘膜。检测APC基因突变能预测腺瘤的癌变倾向，有助于早期发现大肠癌。
The PCR-SSCP method was used to analyze mutations in the MCR segment of the APC gene in 30 primary colorectal cancer lesions and 15 normal mucosal tissues. It was found that 60% (18/30) of the primary lesions of colorectal cancer had an APC gene MCR segment. Mutations. The mutation rate was not related to the location of tumor, clinical pathological stage, histological differentiation and lymph node metastasis. The results showed that: APC gene mutation is the early change of colorectal cancer, can be seen in the dysplasia of the mucosa. Detection of APC gene mutations can predict the cancerous tendency of adenomas and help early detection of colorectal cancer.