近几十年的研究证明人类肿瘤可以表达被细胞免疫特异识别的抗原,这一发现加速了以T细胞免疫为基础的抗肿瘤免疫治疗的发展。临床上成功的特异性肿瘤免疫治疗取决于对肿瘤抗原的发现,肿瘤相关抗原的寻找是体液免疫和细胞免疫治疗发展的关键因素。随着分子医学和分子免疫学技术的 In recent decades, studies have demonstrated that human tumors can express antigens that are specifically recognized by cellular immunity, a finding that has accelerated the development of antitumor immunotherapy based on T cell immunity. The clinically successful specific tumor immunotherapy depends on the discovery of tumor antigens, and the search for tumor-associated antigens is a key factor in the development of humoral and cellular immunotherapy. With molecular medicine and molecular immunology techniques