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过氧化物酶体增殖物激活受体γ(PPARγ)是一种配体依赖性核转录因子,具有调控细胞分化、脂肪代谢、糖代谢及炎症等多种生物学功能。已知PPARγ有多种转录后修饰,磷酸化修饰是PPARγ第一个被鉴定的翻译后修饰方式,目前研究较多的是Ser112位点的丝裂原激活的蛋白激酶途径及Ser273位点的细胞周期素依赖的蛋白激酶5途径。PPARγ的异源二聚体结合到靶基因启动子区的特异反应元件过氧化物酶体增殖反应元件上调控靶基因的转录,PPARγ还参与炎性反应应答。PPARγ与糖尿病、肿瘤等疾病也有密切的联系。
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent nuclear transcription factor that regulates a variety of biological functions such as cell differentiation, fat metabolism, glucose metabolism and inflammation. PPARγ is known to have a variety of post-transcriptional modifications. Phosphorylation is the first post-translational modification of PPARγ. At present, more studies are focused on the mitogen-activated protein kinase pathway of Ser112 and the cells of Ser273 Cyclin-dependent protein kinase 5 pathway. Heterodimers of PPARγ bind to specific response elements in the promoter region of the target gene Peroxisomal proliferative response elements regulate the transcription of target genes, and PPARγ is also involved in the inflammatory response. PPARγ and diabetes, cancer and other diseases are also closely linked.