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目的 :探讨益中蠲毒浓缩丸对免疫功能的影响 ,揭示其抗胃癌的作用机制。方法 :对脾虚型小鼠以刀豆素 (Con A)或脂多糖 (L PS)作诱导剂 ,通过体内给药 ,体外实验的方法 ,观察该药对 T、B淋巴细胞增殖反应的影响。结果 :给脾虚小鼠灌服 8.4g生药 / kg的受试药 ,能明显提高其 T、B淋巴细胞增殖反应。结论 :益中蠲毒浓缩丸能明显提高脾虚小鼠细胞免疫及体液免疫的功能 ,其抗胃癌作用是通过提高免疫功能等多途径、综合协同实现的。
Objective: To investigate the effect of Yizhong Quyu Pill on immune function and reveal its mechanism of anti-gastric cancer. Methods : The spleen deficiency mice were treated with concanavalin (Con A) or lipopolysaccharide (LPS) as inducing agent. The effects of the drug on the proliferative responses of T and B lymphocytes were observed by in vitro test. RESULTS : Spleen mice were given 8.4 g crude drug/kg of test drug, which significantly increased the T and B lymphocyte proliferation responses. Conclusion : Yizhong Quxue Pill can significantly improve the function of cellular immunity and humoral immunity in mice with spleen deficiency. Its anti-gastric cancer effect is achieved through multiple ways, such as improving immunity.