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目的探讨妊娠期高血压、轻度子痫前期、重度子痫前期患者血脂代谢特点,了解血脂代谢紊乱与妊娠期高血压疾病的关系。方法收集395例妊娠期高血压疾病患者分为3组:妊娠期高血压组31例,子痫前期轻度组198例,子痫前期重度组166例。同时选择无妊娠并发症的健康孕妇200例为对照组。检测血清总胆固醇(CHOL)、甘油三脂(TRIG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A1(APOA)、载脂蛋白B100(APOB)、脂蛋白a(LPa)进行比较。结果 3组血脂水平TRIG、HDL-C与对照组比较均有显著性差异(P均<0.05),LPa与对照组比较均无显著性差异(P≥0.05)。结论 PIH患者随着病情不断加重,血脂代谢紊乱越来越突出,加强血脂监测,及早干预并纠正紊乱以保证母婴健康。
Objective To investigate the characteristics of blood lipid metabolism in patients with gestational hypertension, mild preeclampsia and severe preeclampsia and to understand the relationship between dyslipidemia and hypertensive disorder complicating pregnancy. Methods 395 cases of hypertensive disorder complicating pregnancy were divided into 3 groups: 31 cases of hypertensive pregnancy group, 198 cases of mild preeclampsia group and 166 cases of severe preeclampsia group. At the same time, 200 healthy pregnant women without pregnancy complications were selected as the control group. Serum total cholesterol (CHOL), triglyceride (TRIG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A1 (APOA), apolipoprotein B100 , Lipoprotein a (LPa) for comparison. Results There were significant differences in blood lipid levels TRIG and HDL-C among the three groups (all P <0.05). There was no significant difference between LPa and control group (P> 0.05). Conclusion PIH patients with worsening condition, blood lipid metabolism disorders become more prominent, to strengthen blood lipid monitoring, early intervention and correct disorders to ensure maternal and child health.