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目的 研究卵巢癌经手术化疗后复发再化疗的第二线化疗方案。方法 选择曾做过手术,接受过多疗程联合化疗,病人有可测得的不小于2.0cm的肿瘤,一个月内无化疗史,未接受过放疗,血象及肝肾功正常,病理证实的各种卵巢复发癌作为治疗对象,用DDP或卡铂与异环磷酰胺联合化疗,美施钠解毒。以完成两个疗程后肿瘤变化判定疗效,以完成一个疗程后的各种毒性表现判定毒性。结果 可评估疗效的24例病人中完全效应为0,部分效应为29％,稳定为50％,无效为20.8％。可判定毒性的43例病人中,全部病人可以耐受不同程度的付反应。在应用异环磷酰胺化疗同时用美施钠解毒,无出血性膀胱炎病例发生。结论 DDP或卡铂与异环磷酰胺联合化疗在卵巢复发癌患者的补救治疗中有一定作用,且付反应病人可以耐受。
Objective To study the second-line chemotherapy for the recurrence and re-chemotherapy of ovarian cancer after surgery and chemotherapy. Methods of choice Have done surgery, received too much course of treatment combined with chemotherapy, the patient has measurable tumor of not less than 2.0cm, no chemotherapy within a month history, did not receive radiotherapy, blood and liver and kidney function normal, confirmed by pathology Breeding ovarian cancer as a treatment object, with DDP or cisplatin and carboplatin chemotherapy, sodium detoxification. To complete the two course of treatment to determine the efficacy of tumor changes in order to complete a course of treatment after a variety of toxicological performance to determine toxicity. Results The complete response was 0 in 24 patients with evaluable efficacy, with a partial effect of 29%, a stable 50%, and a null effect of 20.8%. Of the 43 patients who were judged toxic, all patients were able to tolerate varying degrees of response. In the application of ifosfamide chemotherapy at the same time with the United States Shi detoxification, no cases of hemorrhagic cystitis. Conclusion DDP or carboplatin and ifosfamide combined chemotherapy in the treatment of ovarian cancer patients have a role in the remedial treatment, and response to patients can be tolerated.