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抗中性粒细胞胞浆抗体(ANCA)是一种中性粒细胞(PMN)的自身抗体,其中胞浆型(C-ANCA)的抗原是蛋白酶3,核周型(P-ANCA)的抗原系髓过氧化物酶。ANCA既可通过激活PMN直接损伤组织;也可干扰酶活性加剧组织损伤;还可诱发免疫反应损伤组织。因此,ANCA在急进性肾小球肾炎、系统性红斑狼疮性肾炎和Wegener氏肉芽肿肾损害中起主要致病作用。大剂量环磷酰胶或大剂量免疫球蛋白对本病疗效较高。
Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies to neutrophils (PMNs) in which cytoplasmic (C-ANCA) antigens are protease 3, perinuclear type (P-ANCA) Department of myeloperoxidase. ANCA can directly damage the tissue by activating the PMN; also interfere with enzyme activity aggravate tissue damage; can also induce immune response to damage the tissue. Therefore, ANCA plays a major pathogenic role in aggressive glomerulonephritis, systemic lupus nephritis and Wegener’s granulomatous kidney damage. High-dose cyclophosphamide or high-dose immunoglobulin on the disease more effective.