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目的 :比较昆明三戍贵金属药业有限公司国产顺铂水针剂 (Ⅰ )与进口科鼎 (Faulding)公司顺铂水针剂(Ⅱ )的抗肿瘤效果。方法 :MTT法分别对 (Ⅰ )与 (Ⅱ )进行体外抗肿瘤作用活性测定 ,比较其半数抑制生长浓度(IC50 ) ,评价其抗肿瘤效果。结果 :(Ⅰ )与 (Ⅱ )对鼻咽癌细胞株CNE2 的IC50 分别为 2 7± 0 8及 4 2± 1 7μg/ml,差别具有显著性 (P <0 0 5) ;(Ⅰ )与 (Ⅱ )对乳腺癌细胞株MCF -7的IC50 分别为 2 5± 0 6及 4 9± 1 8μg/ml,差别具有显著性 (P <0 0 5)。结论 :(Ⅰ )体外抗肿瘤效果比 (Ⅱ )强
OBJECTIVE: To compare the anti-tumor effects of domestic cisplatin aqueous solution (Ⅰ) and imported Faulding company’s cisplatin aqueous solution injection (Ⅱ) of Sanshu Precious Metal Industry Co., Ltd. in Kunming. Methods: The antitumor activity of (Ⅰ) and (Ⅱ) were determined by MTT method respectively. The half inhibitory concentration (IC50) was compared to evaluate its antitumor effect. Results: The IC50 values of (Ⅰ) and (Ⅱ) on nasopharyngeal carcinoma cell line CNE2 were 27 ± 0 8 and 42 ± 1 7 μg / ml, respectively, with significant difference (P <0.05) (Ⅱ) on breast cancer cell line MCF-7 with IC50 of 25 ± 0 6 and 49 ± 18 μg / ml respectively, the difference was significant (P <0 05). Conclusion: (Ⅰ) anti-tumor effect in vitro (Ⅱ) than strong