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目的:观察荆花胃康胶丸联合兰索拉唑、呋喃唑酮、阿莫西林“三联”疗法治疗消化性溃疡(PU)的疗效和根除幽门螺旋杆菌(Hp)的效果。方法:将128例幽门螺旋杆菌(Hp)感染阳性消化性溃疡患者随机分为治疗组68例和对照组60例,对照组给予兰索拉唑20mg,2次/d,呋喃唑酮100mg、阿莫西林500mg,均口服,3次/d。治疗组在对照组基础上加服荆花胃康胶丸160 mg,3次/d,口服。2组疗程均为4～8周。观察在治疗前后溃疡愈合率和幽门螺旋杆菌根除情况。结果:治疗组和对照组溃疡愈合率分别为91.2%和88.7%,无显著性差异(P>0.05),幽门螺旋杆菌清除率分别为94.5%和86.7%,有显著性差异(P<0.05)。结论:荆花胃康胶丸联合兰索拉唑、呋喃唑酮、阿莫西林治疗消化性溃疡不仅具有较好的溃疡愈合率而且可提高幽门螺旋杆菌清除率。
Objective: To observe the curative effect of Jinghua Weikang Pills combined with lansoprazole, furazolidone and amoxicillin / triple therapy on the treatment of peptic ulcer (PU) and the eradication of Helicobacter pylori (Hp). Methods: 128 patients with H.pylori-positive peptic ulcer were randomly divided into treatment group (n = 68) and control group (n = 60). The control group was treated with lansoprazole 20 mg twice daily, furazolidone 100 mg, amoxicillin 500mg, all oral, 3 times / d. On the basis of the control group, the treatment group added Jinghua Weikang Capsule 160 mg three times a day orally. 2 groups of treatment are 4 to 8 weeks. Observe the ulcer healing rate and Helicobacter pylori eradication before and after treatment. Results: The healing rates of ulcer in treatment group and control group were 91.2% and 88.7% respectively, with no significant difference (P> 0.05). The H. pylori clearance rate was 94.5% and 86.7% respectively, with significant difference (P <0.05) . Conclusion: Jinghuaweikang injection combined with lansoprazole, furazolidone and amoxicillin not only has better ulcer healing rate but also can improve the clearance rate of Helicobacter pylori.