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目的武汉某校发生过一次肠道传播型肝炎流行,从粪便中检出与TT病毒同源的病毒,随访调查以了解这一新型病毒的感染过程。方法急性期和随访血清检测ALT和病毒片段。结果急性期、发病后6个月和18个月ALT增高分别为100%,29.6%和13.9%;检出病毒片段分别有77.0%,685%和18.5%。18个月时ALT正常者病毒血症也消失的80.6%;ALT增高的15例病人仅2例(133%)检出病毒,可能因此时病毒水平多低于可检出水平。结论这一病毒可长期血液携带,其血液传播的重要性,远非甲型肝炎和成型肝炎病毒所可比拟。
Objective An epidemic of enteric hepatitis in a school in Wuhan occurred. A virus homologous to TT virus was detected in the stool. The follow-up investigation was conducted to understand the infection process of this new virus. Methods Acute phase and follow-up serum were used to detect ALT and virus fragments. Results In the acute phase, the ALT levels were 100%, 29.6% and 13.9% at 6 months and 18 months after onset respectively. The detected fragments were 77.0%, 685% and 18.5% respectively. At 18 months, 80.6% of patients with normal ALT viremia also disappeared; only 2 (15%) of the 15 patients with elevated ALT detected the virus, and as a result, the virus levels were much below detectable levels. Conclusion The virus can be carried by long-term blood, the importance of its blood transmission, far from the hepatitis A and hepatitis B virus can be compared.