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目的探讨不同年龄和血压水平的高血压病患者颈-股动脉和颈-桡动脉脉搏波速度的改变及其影响因素。方法应用脉搏波速度(pulse wave velocity,PWV)自动测量系统测定颈-股动脉PWV(CFPWV)和颈-桡动脉PWV(CRPWV)分别作为反映中央弹性大动脉和外周中等肌性动脉弹性功能的指标,对517例高血压患者[其中男272例,女245例,年龄17~82岁,平均(52.0±13.0)岁]和118例健康人[其中男52例,女66例,年龄19~82岁,平均(54.2±13.8)岁]进行PWV检测。结果健康人和高血压病患者颈-股动脉PWV均随年龄增大而增加(P<0.001),而颈-桡动脉PWV无此变化趋势;颈-股动脉PWV和颈-桡动脉PWV均随血压水平升高而增高(P<0.001)。多元逐步回归显示,年龄和收缩压是影响颈-股动脉PWV的独立因素;舒张压是影响颈-桡动脉PWV的独立因素(各标准化回归系数P<0.001)。结论年龄和血压组分对高血压患者中央弹性大动脉和外周中等肌性动脉弹性功能的影响不同。对大动脉弹性功能改变的检测较外周中等动脉有更重要的临床价值。
Objective To investigate the changes of pulse wave velocity of cervical-femoral artery and cervical-radial artery in hypertension patients with different age and blood pressure levels and its influencing factors. Methods The pulse-wave velocity (PWV) automatic measurement system was used to measure the elasticity of the neck-femoral artery PWV (CFPWV) and the carotid-radial artery PWV (CRPWV) as an index to reflect the elastic function of the central elastic artery and the peripheral mid- A total of 517 hypertensive patients (272 males and 245 females, aged 17-82 years, mean age 52.0 ± 13.0 years) and 118 healthy subjects (including 52 males and 66 females, aged 19-82 years , Mean (54.2 ± 13.8) years old]. Results The PWV of cervical-femoral artery in both healthy and hypertensive patients increased with age (P <0.001), while there was no change in the PWV of the carotid-radial artery. The PWV of the cervical-femoral artery and the PWV of the cervical-radial artery were Blood pressure increased and increased (P <0.001). Multiple stepwise regression showed that age and systolic blood pressure were independent factors affecting PWV of the neck-femoral artery. Diastolic pressure was an independent factor affecting the PWV of the carotid-radial artery (P <0.001 for each standardized regression coefficient). Conclusion Age and blood pressure components have different effects on the elastic function of central elastic artery and peripheral middle muscular artery in patients with essential hypertension. The detection of changes in the elasticity of the aorta has more important clinical value than the peripheral medium arteries.