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目的探讨路优泰在早期帕金森病伴抑郁症的临床治疗效果。方法 72例早期帕金森病伴抑郁症患者随机分为治疗组37例和对照组35例。对照组仅用抗帕金森病药物治疗,不使用抗抑郁药。治疗组在常规治疗的基础上加用路优泰。分别在治疗前及治疗后2、4和8周通过流调用抑郁自评量表(CES-D)对患者抑郁状况进行评价。结果治疗后,治疗组CES-D评分明显低于对照组,差异有统计学意义(P<0.05);两组疗效比较差异有统计学意义(P<0.05)。结论路优泰治疗早期帕金森病合并抑郁症状疗效显著,耐受性良好,可明显且快速改善患者的抑郁症状。
Objective To investigate the clinical effect of Lu You-tai in the early stage of Parkinson’s disease with depression. Methods 72 patients with early Parkinson’s disease and depression were randomly divided into treatment group (37 cases) and control group (35 cases). The control group was treated with anti-Parkinson’s disease drugs only and did not use antidepressants. Treatment group in the conventional treatment based on the use of Lu You-tai. Patients were assessed for depression by flow-mediated depression self-rating scale (CES-D) before treatment and at 2, 4, and 8 weeks after treatment. Results After treatment, the CES-D score of the treatment group was significantly lower than that of the control group (P <0.05). There was significant difference between the two groups in curative effect (P <0.05). Conclusion Lu You-tai treatment of early Parkinson’s disease with depression symptoms significantly effect, well tolerated, can significantly and rapidly improve the patient’s depressive symptoms.