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家族性非髓样甲状腺癌(FNMTC)作为甲状腺癌的一种,存在遗传倾向,属常染色体显性遗传并伴有不完全显性。本文对各种FNMTC家系进行基因连锁分析,染色体定位研究,进一步证实了其遗传聚集倾向,并确定了1q21、19p13.2、2q21、14q32等染色体位点是较为可能的易感基因可能存在的位点假设,但单发FNMTC的易感基因还未最终确定。因此,收集其大家系多样本,开展多染色体位点研究、多中心分析,采用更综合的、更先进的生物学分析方法,将是我们对FNMTC进一步研究的必经之路。
Familial non-myeloid thyroid cancer (FNMTC) as a thyroid cancer, there is a genetic predisposition, autosomal dominant inheritance with incomplete dominant. In this study, we conducted genetic linkage analysis and chromosomal localization studies on a variety of FNMTC pedigrees to further confirm their genetic aggregation propensity and determined that the possible sites of susceptibility genes such as 1q21, 19p13.2, 2q21 and 14q32 are possible Point assumptions, but the single gene susceptibility to FNMTC has not been finalized. Therefore, collecting a large sample of pedigrees, conducting multi-chromosome locus research, multicenter analysis and using more comprehensive and advanced biological analysis methods will be the only way for us to further study FNMTC.