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目的探讨Napsin A在子宫内膜样腺癌(EC)、子宫内膜透明细胞癌(ECCC)、子宫内膜浆液性乳头状腺癌(UPSC)中的表达及其意义。方法应用免疫组织化学SP法分别检测30例EC、10例ECCC及20例UPSC中Napsin A的表达,同时分析其对EC、ECCC和UPSC诊断的敏感性和特异性。结果 Napsin A的阳性表达与子宫内膜癌的组织学类型密切相关。Napsin A在EC、ECCC、UPSC中的阳性表达率分别为0、80%、15%(P<0.05)。结论对于子宫内膜透明细胞癌,Napsin A是种敏感而特异的分子标志物,在子宫内膜癌不同组织学类型的鉴别诊断中具有应用价值。
Objective To investigate the expression and significance of Napsin A in endometrial adenocarcinoma (EC), endometrial clear cell carcinoma (ECCC) and endometrial serous papillary adenocarcinoma (UPSC). Methods The expressions of Napsin A in 30 cases of EC, 10 cases of ECCC and 20 cases of UPSC were detected by immunohistochemical SP method. The sensitivity and specificity of Napsin A in EC, ECCC and UPSC were also analyzed. Results The positive expression of Napsin A was closely related to the histological type of endometrial carcinoma. The positive rates of Napsin A in EC, ECCC and UPSC were 0, 80% and 15%, respectively (P <0.05). Conclusion Napsin A is a sensitive and specific molecular marker for endometrial clear cell carcinoma, which is of value in the differential diagnosis of different histological types of endometrial cancer.