论文部分内容阅读
目的 观察直肠癌术前应用５－氟尿嘧啶（５－Ｆｕ）栓剂的疗效。方法 将５５例入院行根治性手术的直肠癌患者随机分成两组，Ｔ组３０ 例，术前应用５－Ｆｕ 栓剂；Ｃ组２５例，术前５－Ｆｕ 静脉滴注化疗。结果 Ｔ组一般症状减轻率为１００％ ，与Ｃ组比较，Ｐ＜ ０．０１；Ｔ组术后癌细胞均有不同程度的组织学改变，其中Ⅰ级变化率１３．３％ ，Ⅱ级７０％ ，Ⅲ级１６．７％ ，以Ⅱ～Ⅲ级改变作为有效的判定指标，有效率为８６．７％ ，与Ｃ组比较，Ｐ＜ ０．０１；不良反应方面，Ｃ组部分病人出现血红蛋白、白细胞下降、脱发、肝脏损害等毒副反应，而Ｔ组未见此类不良反应，仅少数病人出现局部刺激症状。结论 术前应用５－Ｆｕ 栓剂疗效较静脉滴注５－Ｆｕ 化疗优，且不良反应低。
Objective To observe the effect of preoperative application of 5-fluorouracil (5-Fu) suppository. Methods Fifty-five patients with rectal cancer undergoing radical surgery were randomly divided into two groups. T group (n = 30) received 5-Fu suppository before operation. C group (n = 25) received chemotherapy before operation. Results The general symptom relief rate was 100% in T group, P <0.01 compared with that in C group. There were some histological changes in T group after operation, in which grade Ⅰ changed rate was 13.3%, grade Ⅱ 70 %, Ⅲ grade 16.7%, Ⅱ ~ Ⅲ grade change as an effective indicator, the effective rate was 86.7%, compared with the C group, P <0.01; adverse reactions, C group of patients with hemoglobin , Leukopenia, alopecia, liver damage and other toxic side effects, while the T group no such adverse reactions, only a few patients with local irritation. Conclusions The preoperative application of 5-Fu suppository is superior to intravenous infusion of 5-Fu chemotherapy with low adverse reaction.