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目的:观察安替可胶囊联合化疗治疗晚期胃癌的疗效及安全性。方法:将120例患者随机配对分为2组各60例,均接受至少2个周期SOX方案化疗,治疗组患者同时给予安替可胶囊治疗。进行疗效、毒副作用及生活质量观察。结果:治疗组近期客观有效率为63.3%,疾病控制率为91.7%;对照组近期客观有效率为50.0%,疾病控制率为76.7%。经χ2检验,治疗组疾病控制率高于对照组,差异有显著性意义(P<0.05)。治疗后KPS评分改善治疗组为32例(53.3%);对照组为21例(35.0%),治疗组优于对照组,差异有显著性意义(P<0.05)。2组发生血液学及非血液学毒副作用主要有骨髓抑制、消化道反应、肝肾功能损害、神经毒性,但损伤程度均较轻,以Ⅰ、Ⅱ度为主,治疗组患者的白细胞、血红蛋白及血小板下降均少于对照组,差异有显著性意义(P<0.05)。2组随访,无进展生存期治疗组为8.5月,对照组为7.2月。结论:安替可胶囊联合SOX方案化疗可提高晚期胃癌患者的疾病控制率和生活质量,减轻化疗毒副作用。
Objective: To observe the efficacy and safety of Antipyrod capsule combined with chemotherapy in the treatment of advanced gastric cancer. Methods: A total of 120 patients were randomly assigned to two groups of 60 patients, receiving at least 2 cycles of SOX regimen. The patients in the treatment group were given ampicillin capsules simultaneously. Efficacy, side effects and quality of life observation. Results: The objective effective rate in the treatment group was 63.3% and the disease control rate was 91.7%. The objective effective rate in the control group was 50.0% and the disease control rate was 76.7%. The χ2 test, the treatment group disease control rate was higher than the control group, the difference was significant (P <0.05). The improvement of KPS score after treatment was observed in 32 cases (53.3%) in the treatment group and 21 cases (35.0%) in the control group. The treatment group was superior to the control group with significant difference (P <0.05). The hematological and non-hematological toxicities and side effects in group 2 mainly included myelosuppression, digestive tract reaction, liver and kidney dysfunction, and neurotoxicity, but the degree of lesion was mild. The levels of leukocyte and hemoglobin And thrombocytopenia were less than the control group, the difference was significant (P <0.05). Two groups were followed up, progression-free survival treatment group was 8.5 months, the control group was 7.2 months. Conclusion: Allitox capsules combined with SOX regimen can improve the disease control rate and quality of life of patients with advanced gastric cancer and reduce the side effects of chemotherapy.