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大量流行病学的调查资料表明,高密度脂蛋白(high density lipoprotehn,HDL)是一种抗动脉粥样硬化的脂蛋白,有报告指出,血清 HDL-胆固醇含量高的人,其寿命也相对较长。因而引起人们对此类脂蛋白的极大兴趣,并对其组成、结构、功能、代谢及其与冠心病的关系等方面进行广泛深入的研究。本文拟就这一领域中近年来与临床关系较密切的进展作简要综述。HDL 的组成成分在超速离心中,密度为1.063～1.200g/ml范围内的脂蛋白部分统称为高密度脂蛋白(HDL)。HDL 不论在密度、颗粒大小和化学组成方面都是极不均一的。从密度上说,它包括2类:即 HDL_2——密度范围为1.063～1.125g/ml 和 HDL_3——密度范围为1.125～1.210g/ml。据新近报告,HDL_2还可分为 HDL_(2a)。和 HDL_(2b)
A large number of epidemiological survey data show that high density lipoprotein (HDL) is an anti-atherogenic lipoprotein, there are reports that people with high serum HDL-cholesterol levels are also relatively life expectancy long. Which caused great interest in this kind of lipoprotein, and conducted extensive and in-depth research on its composition, structure, function, metabolism and its relationship with coronary heart disease. This article is intended to give a brief overview of the progress made in this area in recent years that is more clinically relevant. Components of HDL In ultracentrifugation, the portions of lipoproteins having a density in the range of 1.063 to 1.200 g / ml are collectively referred to as high density lipoprotein (HDL). HDL is highly heterogeneous in terms of density, particle size and chemical composition. In terms of density, it includes two categories: HDL_2 - with densities ranging from 1.063 to 1.125 g / ml and HDL_3 - with densities ranging from 1.125 to 1.210 g / ml. According to a recent report, HDL_2 can also be divided into HDL_ (2a). And HDL_ (2b)