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目的探讨结直肠癌组织中细胞胀亡及其与微血管密度(microvesseldensity,MVD)的关系和临床意义。方法利用透射电镜和免疫组化技术对64例结直肠癌组织中细胞胀亡与MVD进行检测。结果结直肠癌组织中存在细胞胀亡;结直肠癌组织中胀亡指数(oncosisindex,OI)随分化程度降低而降低(F=85902,P<0005);淋巴结转移组OI明显低于无淋巴结转移组(t=20630,P<005);MVD在淋巴结转移组高表达,无淋巴结转移组低表达(t=32733,P<0005)。MVD高表达组的OI低于低表达组(t=24108,P<001)。结论细胞胀亡和MVD表达与结直肠癌的生物学行为密切相关。
Objective To investigate the relationship between the cell swelling and infiltration in colorectal cancer and its relationship with microvessel density (MVD) and its clinical significance. Methods Transmission electron microscopy and immunohistochemistry were used to detect cell expansion and MVD in 64 cases of colorectal cancer. Results The oncosis index (OI) in colorectal cancer tissues decreased with the degree of differentiation decreasing (F = 85902, P <0005). The OI in lymph node metastasis was significantly lower than that without lymph node metastasis Group (t = 20630, P <005). MVD was highly expressed in lymph node metastasis group, but not in lymph node metastasis group (t = 32733, P <0005). OI in MVD high expression group was lower than that in low expression group (t = 24108, P <001). Conclusion The expression of MVD and cell apoptosis are closely related to the biological behavior of colorectal cancer.