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目的探索婴儿变应性疾病与脐血细胞因子及成长环境因素的关系,筛选早期监测指标,为开展早期干预提供科学依据。方法以2011年6月~2012年6月在义乌市妇幼保健院分娩的父母常住本地或有固定联系方式的婴儿为研究对象。开展病例对照研究。开展问卷调查和随访,并采集其新生儿脐血样本,测定IgE、嗜酸性粒细胞、IL-13、Eotaxin、IL-9、IL-6、IL-4、IL-5、IFN-γ、IL-10指标,采用logistic回归分析婴儿变应性疾病的危险因素。结果婴儿变应性疾病组39例,对照组97例。母亲怀孕时被动吸烟:OR及95%CI为5.65(1.94~16.39),IL-13:OR及95%CI为1.36(1.06~1.74),IL-5:OR及95%CI为0.25(0.10~0.57),IFN-γ:OR及95%CI为1.01(1.00~1.02),IL-10:OR及95%CI为1.25(1.02~1.54),差异均有统计学意义(P<0.05)。结论应开展新生儿脐血细胞因子的监测,IL-13,IL-5,IFN-γ,IL-10是新生儿脐血筛查较为敏感的指标。同时,要加强健康教育,避免孕期被动吸烟,早期预防变应性疾病的发生。
Objective To explore the relationship between infant allergic diseases and umbilical cord blood cytokines and environmental factors of growth and screen early monitoring indicators to provide a scientific basis for early intervention. Methods From June 2011 to June 2012 in Yiwu MCH maternity and childbirth parents living in the local or fixed contact with the baby as the research object. Case-control study. The questionnaire and follow-up were conducted. Cord blood samples of neonates were collected to determine IgE, eosinophil, IL-13, Eotaxin, IL-9, IL-6, IL-4, IL-5, IFN- -10 indicators, the use of logistic regression analysis of infant risk factors for allergic diseases. Results 39 cases of infantile allergic disease group, 97 cases of control group. Passive smoking during pregnancy was 5.6% (1.94 ~ 16.39) for OR and 95% CI, 1.36 (1.06-1.74) for IL-13: OR and 95% CI for 0.25% 0.57). The differences of IFN-γ: OR and 95% CI were 1.01 (1.00-1.02), IL-10: OR and 95% CI were 1.25 (1.02-1.54). There were significant differences between the two groups (P <0.05). Conclusion The monitoring of neonatal umbilical cord blood cytokines should be carried out. IL-13, IL-5, IFN-γ and IL-10 are the sensitive indicators of neonatal cord blood screening. At the same time, we must strengthen health education, to avoid passive smoking during pregnancy, early prevention of allergic diseases.