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目的:观察欣胃颗粒治疗胃癌前病变(GPL)的临床疗效。方法:将62例由胃镜和病理学诊断为GPL的患者随机分为两组。治疗组28例用欣胃颗粒治疗,对照组28例用胃复春片治疗,治疗期间停服其他药物,疗程均为12周。结果:症状总有效率治疗组96.88%,对照组80.00%(P<0.05);治疗组在黏膜萎缩、肠化及不典型增生改善程度上均明显高于对照组,两组比较有显著性差异(P<0.05);治疗组及对照组治疗后血清EGF表达均有显著降低,而治疗组较对照组降低更为明显(P<0.05)。结论:欣胃颗粒可明显改善临床症状,并可以通过适当降低血清EGF的表达水平使胃黏膜病理状态有所逆转。
Objective: To observe the clinical effect of Xinwei granule in treating gastric precancerous lesions (GPL). Methods: Sixty-two patients with GPL diagnosed by endoscopy and pathology were randomly divided into two groups. In the treatment group, 28 cases were treated with Xinwei granule, while in the control group, 28 cases were treated with Weifuchun tablets. Other drugs were stopped during treatment, and the courses of treatment were 12 weeks. Results: The total effective rate was 96.88% in the treatment group and 80.00% in the control group (P <0.05). The improvement rate of mucosal atrophy, intestinal metaplasia and dysplasia in the treatment group was significantly higher than that in the control group, with significant difference between the two groups (P <0.05). The levels of EGF in serum in treatment group and control group were significantly lower than those in control group (P <0.05). Conclusion: Xinwei granule can significantly improve clinical symptoms, and can reverse the pathological changes of gastric mucosa by appropriately reducing the expression of serum EGF.