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目的探讨石榴皮提取物阴道泡腾片(SLP)治疗外阴阴道念珠菌病的药理作用。方法观察SLP对二甲苯引起小鼠耳肿胀模型、大鼠足跖肿胀模型、大鼠棉球肉芽肿模型的影响,考察其对炎症反应的作用;观察SLP对豚鼠止痒实验模型的影响,考察其对阴道瘙痒反应的作用;观察SLP对家兔霉菌性阴道炎的影响,考察其对霉菌性阴道炎的作用。结果与空白对照组比较,SLP高剂量组抑制小鼠耳肿胀效果明显,差异有统计学意义(P<0.05);大鼠足跖肿胀实验中,SLP低、中、高剂量组与空白对照组比较差异均有统计学意义(P<0.05);大鼠棉球肉芽肿引起的急性、亚急性炎症实验中,SLP低、中、高剂量与空白对照组比较差异有统计学意义(P<0.05);在豚鼠致痒实验中,SLP中、高剂量均能明显提高豚鼠致痒阈的作用,与空白对照组比较差异有统计学意义(P<0.05);在霉菌性阴道炎家兔给药实验中,各给药组与模型组相比有明显的治疗作用,且有一定的量效关系,中剂量组和高剂量组尤其明显。结论石榴皮提取物阴道泡腾片有较强的抑制白色念珠菌及抗炎止痒作用。
Objective To investigate the pharmacological effects of pomegranate peel extract vaginal effervescent tablets (SLP) in the treatment of vulvovaginal candidiasis. Methods The effects of SLP on the ear swelling model induced by xylene, rat paw edema model and the model of cotton ball granuloma in mice were observed and the effect of SLP on the anti-itch model was observed Its effect on the vaginal pruritus reaction; observed SLP on fungal vaginitis in rabbits to investigate its effect on fungal vaginitis. Results Compared with the blank control group, the SLP high dose group inhibited the ear edema in mice significantly (P <0.05). In the rat paw edema test, SLP low, middle and high dose groups were significantly different from the blank control group (P <0.05). In acute and subacute inflammation caused by cotton ball granuloma in rats, the SLP low, middle and high doses had significant difference compared with the blank control group (P <0.05 ); In guinea pig pruritus experiment, medium and high doses of SLP can significantly improve the itch threshold of guinea pigs, compared with the blank control group, the difference was statistically significant (P <0.05); in the fungal vaginitis rabbit administration In the experiment, each treatment group had a significant therapeutic effect compared with the model group, and had a certain dose-effect relationship, especially in the middle dose group and the high dose group. Conclusion pomegranate peel extract of vaginal effervescent tablets have a strong inhibition of Candida albicans and anti-inflammatory anti-itch effect.