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目的 :探讨血浆内毒素(ET)、肿瘤坏死因子(TNF α)在酒精性脂肪肝发病机制中的作用。方法 :对20例酒精性脂肪肝以及对照组测定其血清酶(ALT、AST、GGT)与血浆ET、TNF α ,并对观察组血清酶与血浆ET、TNF α作动态观察及相关分析。结果 :观察组血浆ET、TNF α与对照组存在显著性差异(P<0 05) ,观察组血清酶(ALT、AST、GGT)与血浆ET成正相关(r分别为0 434、0 586和0 734) ,与TNF α也成正相关(r分别为0 746、0 638、0 874)。结论 :酒精性脂肪肝的发生、发展与血浆ET、TNF α密切相关
Objective: To investigate the role of plasma endotoxin (ET) and tumor necrosis factor (TNF) in the pathogenesis of alcoholic fatty liver. Methods: 20 cases of alcoholic fatty liver and control group were measured serum enzyme (ALT, AST, GGT) and plasma ET, TNFα, and the observation group of serum enzyme and plasma ET, TNFα dynamic observation and correlation analysis. Results: There was a significant difference between the observation group and the control group (P <0.05). Serum enzyme (ALT, AST, GGT) in the observation group was positively correlated with plasma ET (r = 0 434, 0 586 and 0 respectively 734) and also positively correlated with TNFα (r = 0 746,0 638,0 874, respectively). Conclusion: The occurrence and development of alcoholic fatty liver are closely related to plasma ET and TNFα