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目的探讨并分析正常人对照组及慢性乙型肝炎患者外周血中MDSCs含量与病毒载体、疾病预后的关系。方法分别用流式细胞仪检测健康人和慢性乙型肝炎患者外周血MDSCs含量,并进行病毒载量和疾病预后资料的相关分析。结果慢性乙型肝炎组的MDSCs百分含量相与正常对照组相比,显著增多(P<0.05);而且通过病例资料分析发现MDSCs含量不仅随着慢性HBV病重程度逐级升高,而且与慢性乙肝疾病预后HBV-DNA含量密切相关。结论 MDSCs可作为慢性乙型肝炎的一种新型血清标志物,用于患者的诊断和预后指标。
Objective To investigate and analyze the relationship between the content of MDSCs in peripheral blood of normal control group and chronic hepatitis B patients with the viral vector and disease prognosis. Methods The contents of MDSCs in peripheral blood of healthy people and patients with chronic hepatitis B were detected by flow cytometry, and the correlation between viral load and disease prognosis data was analyzed. Results Compared with the normal control group, the percentages of MDSCs in chronic hepatitis B group were significantly increased (P <0.05). Furthermore, the MDSCs content increased not only with the severity of chronic HBV but also with the level of The prognosis of chronic hepatitis B is closely related to the content of HBV-DNA. Conclusion MDSCs can be used as a new serum marker of chronic hepatitis B for the diagnosis and prognosis of patients.