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目的:观察二甲双胍治疗PCOS的疗效。方法:二甲双胍治疗PCOS患者80例,80例PCOS患者应用二甲双胍500mg/次,3次/天,连续4个月,比较治疗前后体重指数、月经周期、生殖激素水平、排卵率、妊娠率、血糖和胰岛素水平的变化。结果:二甲双胍可降低血LH/FSH比值和雄激素水平(P<0.05),恢复卵巢排卵功能,提高妊娠率,并可降低BMI评分(P<0.05),提高胰岛素的敏感性。结论:二甲双胍单独应用可以改善卵巢的排卵功能,使患者恢复规则的月经周期,降低胰岛素抵抗。
Objective: To observe the efficacy of metformin in the treatment of PCOS. Methods: Metformin was used to treat 80 cases of PCOS patients. 80 cases of PCOS patients were given metformin 500mg / time, 3 times / day for 4 months. Body mass index, menstrual cycle, reproductive hormone, ovulation rate, pregnancy rate, Changes in insulin levels. Results: Metformin reduced blood LH / FSH ratio and androgen levels (P <0.05), restored ovarian function and pregnancy rate, reduced BMI (P <0.05), and increased insulin sensitivity. Conclusion: Metformin alone can improve ovulation ovarian function, so that patients recover the regular menstrual cycle and reduce insulin resistance.