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目的探讨长期家庭氧疗对缓解期慢性阻塞性肺疾病(COPD)患者的临床疗效。方法对丽水市第二人民医院老年科病房确诊的34例COPD患者,随机分为试验组(18例)、对照组(16例),两组均进行常规的抗炎、解痉平喘、祛痰等治疗,试验组在此基础治疗外,缓解期在家庭内应用双鼻导管氧气筒吸氧,氧流量1~2 L/m in,每天吸氧时间至少为15 h,总疗程均为6个月;定期随访患者吸氧的依从性。治疗前缓解期及治疗后测定患者血气分析、红细胞压积、肺功能及评估运动功能及精神状态。结果试验组低氧血症显著改善(P<0.01)、红细胞压积下降(P<0.01),但肺功能变化不明显(P>0.05),最大运动能力及精神状态评估较对照组明显改善。治疗后两组间各项检测指标比较差异有统计学意义(P<0.01)。结论长期家庭氧疗对缓解期COPD的临床疗效确定,明显提高患者生命质量。
Objective To investigate the clinical effect of long-term home oxygen therapy on patients with chronic obstructive pulmonary disease (COPD) during remission. Methods Totally 34 COPD patients diagnosed in Geriatrics Department of Second People’s Hospital of Lishui City were randomly divided into experimental group (n = 18) and control group (n = 16). The two groups were given routine anti-inflammatory, antispasmodic and asthma expectorant Treatment, the experimental group in this basic treatment, remission in the family double nasal cannula oxygen cylinder oxygen flow 1 ~ 2 L / m in, oxygen daily time of at least 15 h, the total duration of treatment were 6 months Regular follow-up of patients with oxygen compliance. Blood gas analysis, hematocrit, lung function and assessment of motor function and mental status were measured before treatment and after treatment. Results The hypoxemia in the experimental group was significantly improved (P <0.01), hematocrit decreased (P <0.01), but pulmonary function did not change significantly (P> 0.05). The maximum exercise capacity and mental status were significantly improved in the experimental group compared with the control group. After treatment, there was significant difference between the two groups (P <0.01). Conclusion Long-term home oxygen therapy for COPD in the remission to determine the clinical efficacy, significantly improve patient quality of life.