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肝纤维化与其他组织的纤维化反应一样 ,可视为一种创伤愈合反应 ,病毒、乙醇、自身免疫等病因均可引起肝细胞的坏死、再生和持续纤维增生 ,当这种创伤愈合反应长时间存在 ,肝脏中多种细胞外基质 (ＥＣＭ)异常积聚 ,逐渐发展为肝硬变。早期肝纤维化是可逆的 ,而肝硬变则为不可逆
Like other tissue fibrosis, hepatic fibrosis can be regarded as a wound healing reaction, and necrosis, regeneration and persistent fibrosis of hepatocytes can be caused by etiology such as virus, ethanol and autoimmune. When such wound healing reaction is long Time exists, the abnormal accumulation of extracellular matrix (ECM) in the liver, and gradually developed into cirrhosis. Early liver fibrosis is reversible, whereas cirrhosis is irreversible