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目的:探讨α-硫辛酸对糖尿病肾病患者的疗效及对氧化应激、同型半胱氨酸(homocysteine,Hcy)、血清胱抑素C(cystatin C,CysC)的影响。方法:将82例于我院进行治疗的2型糖尿病肾病患者随机分为观察组和对照组,对照组患者接受常规治疗,观察组患者在对照组的基础上加用α-硫辛酸。治疗时间均为2周。观察两组治疗效果并比较两组患者治疗前、后氧化应激指标超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)及Hcy、CysC水平变化。结果:治疗后,观察组氧化应激指标SOD水平均较治疗前显著升高(P<0.05),MDA水平均较治疗前显著降低(P<0.05),对照组氧化应激指标SOD及MDA水平与治疗前无明显差异(P>0.05),两组治疗后SOD及MDA水平差异显著(P<0.05);治疗后,观察组Hcy、CysC水平较治疗前显著降低(P<0.05),对照组Hcy、CysC水平与治疗前无明显差异(P>0.05),两组治疗后Hcy、CysC水平差异显著(P<0.05)。结论:α-硫辛酸可缓解糖尿病肾病患者氧化应激状态,降低Hcy、CysC水平,改善患者肾功能。
Objective: To investigate the effects of α-lipoic acid on patients with diabetic nephropathy and its effects on oxidative stress, homocysteine (Hcy) and serum cystatin C (CysC). Methods: 82 patients with type 2 diabetic nephropathy treated in our hospital were randomly divided into observation group and control group. Patients in control group received routine treatment. Patients in observation group were given α-lipoic acid on the basis of control group. Treatment time is 2 weeks. The therapeutic effects of the two groups were observed and the levels of oxidative stress superoxide dismutase (SOD), malondialdehyde (MDA), Hcy and CysC in the two groups were compared before and after treatment. Results: After treatment, the level of SOD in the observation group was significantly higher than that before treatment (P <0.05), and the level of MDA in the observation group was significantly lower than that before treatment (P <0.05). The levels of SOD and MDA in the control group (P <0.05). After treatment, the levels of SOD and MDA in the two groups were significantly different (P <0.05). After treatment, the levels of Hcy and CysC in the observation group were significantly lower than those before treatment (P <0.05) The levels of Hcy and CysC were not significantly different from those before treatment (P> 0.05). The levels of Hcy and CysC were significantly different between the two groups (P <0.05). Conclusion: Alpha-lipoic acid can relieve oxidative stress, reduce Hcy, CysC and improve renal function in patients with diabetic nephropathy.