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目的:探讨二甲双胍在妊娠期糖尿病(GDM)患者血糖控制的疗效及安全性。方法:将68例GDM患者设为实验组,应用二甲双胍进行血糖控制,并选择同期未进行血糖控制的GDM孕妇33例设为对照组1,应用胰岛素控制血糖的82例GDM孕妇为对照组2,观察各组血糖控制情况、妊娠结局以及新生儿情况。结果:实验组与对照组2比较,空腹血糖、餐后2h血糖及糖化血红蛋白治疗前以及治疗后均无统计学差异(P>0.05),治疗后血糖均控制良好;实验组妊娠期高血压疾病、胎膜早破、羊水过多、早产、剖宫产发生率以及新生儿窘迫、高胆红素血症、巨大儿、新生儿低血糖发生率与对照组2比较,无统计学意义(P>0.05),并均低于对照组1(P<0.05)。结论:二甲酸胍对GDM孕妇血糖控制有较好的疗效,安全性较高,适合在临床推广应用。
Objective: To investigate the efficacy and safety of metformin in glycemic control in patients with gestational diabetes mellitus (GDM). Methods: Sixty-eight patients with GDM were enrolled in the study. Metformin was used to control blood glucose. 33 pregnant women with GDM who did not receive blood glucose control during the same period were enrolled as control group 1. 82 GDM pregnant women with insulin control of blood glucose as control group, Observe the blood glucose control, pregnancy outcome and neonatal status in each group. Results: Compared with control group 2, fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin were not significantly different between experimental group and control group 2 after treatment (P> 0.05), and blood sugar was well controlled after treatment. In experimental group, gestational hypertension , Premature rupture of membranes, polyhydramnios, premature delivery, the incidence of cesarean section and neonatal distress, hyperbilirubinemia, macrosomia, neonatal hypoglycemia incidence compared with the control group 2, no statistical significance (P > 0.05), and were lower than the control group 1 (P <0.05). Conclusion: Guanidine dicarboxylate has a good effect on the control of blood glucose in pregnant women with GDM, which is safe and suitable for clinical application.