子宫内膜异位症(EMs)是妇科常见病、疑难病.雌激素在EMs的发生和发展过程中起着十分重要的作用,并通过经典的雌激素受体ERa和ERβ介导的基因或非基因传导通路发挥生物学效应.通过促进炎性反应,减少凋亡,增加异位内膜的黏附、侵袭及血管生成能力,使得子宫内膜异位症具有类似恶性肿瘤的远处转移和种植生长能力,促进了子宫内膜异位症的发生、发展.“,”Endometriosis (EMs) is a common and difficult disease in gynecology. Estrogen plays an important role in the occurrence and development of EMs, and plays a biological role through the classical estrogen receptor ERa or ER beta mediated gene or non-gene transduction pathway. By promoting inflammatory response,reducing apoptosis and increasing the adhesion,invasion and angiogenesis ability of ectopic endometrium,endometriosis has similar distant metastasis and growth a-bility of malignant tumor,and promotes the occurrence and development of endometriosis.